DAY ONE: Begin your journey across Route 6 with a stop at the Welcome Center in Matamoras and proceed onto Milford.

Things to do :
Grey Towers National Historic Site
Walking Tour of Milford
Columns Museum
Upper Delaware Scenic and Recreation River

Overnight in Milford (MM 394)

DAY TWO: Explore the northern part of the Pocono Mountains.

Things to do:
Lake Wallenpaupack & Lake Wallenpaupack Environmental Center
Walking Tour of Hawley
Dorflinger Glass Museum
Walking Tour of Honesdale
Honesdale Historical Society Museum
Walking Tour of Carbondale

Overnight in Carbondale (MM 343-345) or Scranton (MM332)

DAY THREE AND FOUR:  Explore the many historical and cultural offerings of Scranton before heading to the Endless Mountains region of Pennsylvania.

Things to do:

Steamtown National Historic Site
Lackawanna County Coal Mine Tour
Pennsylvania Anthracite Heritage Mine
Scranton Electric City Trolley Station & Museum
Scranton’s Everhart Museum
McDade Park Arboretum
Tunkhannock Viaduct

Overnight on the fourth night in Tunkhannock (MM311)

DAY FIVE: Discover the rich agricultural history of the Endless Mountains.

Things to do:

Walking Tour of Tunkhannock
Wyoming County Court House
Endless Mountain Wine Tour
Laceyville’s Oldest House
Walking Tour of Wyalusing
Quilted Barn Tour
French Azilum Historic Site

Overnight in Towanda (MM 271-272)

DAY SIX: Even though you are entering into the area known at the Pennsylvania Wilds, you can start mildly by first exploring Wellsboro with its Victorian era influences.

Things to do:
Mansfield University
Historic Wellsboro
Tioga County Historical Museum
Leonard Harrison State Park & Pennsylvania’s Grand Canyon

Overnight in Wellsboro (MM 221-222)

DAY SEVEN: Learn about and taste the products of the northern tier today: maple syrup and hardwood timber.

Things to do:
Pine Creek Trail
Patterson’s Maple Farm
Walking tour of a Lumbering Town – Galeton
Pennsylvania Lumber Museum
Coudersport & Potter County Historical Museum
Dark Sky Preserve – Cherry Springs State Park

Overnight in Coudersport (MM 175-178)

DAY EIGHT: Travel to Smethport on Route 6 and then loop up to Eldred and Bradford to discover some fascinating museums full of American history.

Things to do:

Old Jail House Museum
Eldred World War II Museum
Driving Tour of Bradford National Historic District
Zippo/ Case Museum
Penn-Brad Oil Museum
Historic Crook Farm and School House
Walking Tour of Smethport

One nights accommodations at Smethport (MM  149-150)

DAY NINE: Explore the Allegheny National Forest either in a car or on foot.

Kinzua Bridge State Park and Kinzua Skywalk
Longhouse National Scenic Byway
Allegheny Reservior
Kinzua Dam
Artworks at the Kane Depot
Walking Tour of Kane

One nights accommodations at Kane (MM 124 – 125)

DAY TEN:  Here’s your chance to explore both the city of Warren and the mighty Allegheny River that runs through it.

Things to do:

Walking Tour of Warren
Warren County Historical Society
Struthers Library Theater
Chapman State Park
Allegheny Outfitters

Overnight in Warren (MM 94-98)

DAY ELEVEN: As you pass through this part of Route 6, you will be reminded of the first frontier.

Things to do:
Corry Historical Society Museum
Corry Junction Greenway Trail
Union City Historical Society Museum
Union City Art Center
Historical Riverside Inn
Mead’s Log Cabin
Baldwin Reynolds House Museum
Walking Tour of Meadville
John Brown Tannery, Farm & Museum

Overnight in Meadville (MM 23-25)

DAY TWELVE: After finishing visiting all the Meadville sites, take US Route 6 west all the way to the end, stopping in Conneaut Lake and Linesville, before circling back to hop on I-79 a few exits north to Edinboro and Rt. 6N

Things to do:

Conneaut Lake Resort
Pymatuning State Park
Goodell Gardens & Homestead
Edinboro Lake
Fort LeBoeuf Museum

Overnight in Edinboro (MM 20-21N)

DAY THIRTEEN AND FOURTEEN : Take I-79 North into Erie. This city is rich with recreational and cultural offerings.

Things to do:

Erie Maritime Museum
USS Brig Niagara
Presque Isle State Park
Walking Tour of Historic Erie
Splash Lagoon
Erie Zoo
Lake Erie Wine Trail

Overnight in Erie